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4.2.3 Targeting lactylation modification sites In contrast to the aforementioned strategies that indirectly modulate lactylation levels by regulating enzyme activity, a more precise interventional approach involves directly targeting the lactylation modification sites themselves, either by recognizing or blocking pathogenic modification events with specific antibodies, including pan-specific antibodies (anti-pan-Kla) that can identify lactic acid lysine residues in all proteins, and multi-site specific antibodies, such as anti-H3K18la, anti-H3K14la and anti-XRCC1 K247la

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A meta-analysis of more than 300,000 people found that those with strong relationships had a 50 percent higher chance of survival

This indicates an interesting GSH-dependent threshold regulation that is important for the subset-specific functions of B cells and a differential redox-dependent regulation of metabolic activities in these cells

doi: 10.1136/ard-2022-223035 13 Bukulmez HGK